Dresden Files is a very good system, and one I'd recommend. It helps if you have some degree of familiarity with the novels, especially if you're going to play something other than a pure mortal character.
Scion we have run from Hero up to Demigod. Currently we're at Legend 6, but taking a break from it to play other stuff. We tend to rotate games every so often, so we don't get bored with something. Previously we've also ran GURPS, Star Wars, Legend of the Five Rings and a handfull of other games.