Ah, well, the process is somewhat tedious, but I think I'll detail it and when I can, try to get up screenshots. The process is slow and tedious when done perfectly, but you can often take shortcuts.
The basic premise is that the explorer.exe process is most frequently corrupted - so, in order to completely disinfect your machine, you need to get cleaning before it gets loaded. This can be done from the recovery console sometimes, but often that gets broken or can't be used for various reasons.
So, safe mode with command prompt.
If you want to do it the quick, easy, and somewhat familiar way, you can just use ctrl+alt+del, start the task manager, file -> new task -> browse. This does load the task manager, but it isn't corrupted as often as explorer.exe is, and you can function mostly normally, just remember where things get installed and so on.
Try Roguefix and MBAM first. Run them both, reboot into command prompt, run them both again, rinse and repeat until they generate the same results each time. After you start explorer.exe, even in safe mode, you risk losing all progress.
Combofix should be a last resort. It can break things, though not typically on machines not associated with a domain.