If we're talking role played vampires, by far my favorite vampires were the World of Darkness Kindred of the East. They were not truly vampires in the sense that people think of vampire. They were undead corpses, animated by their own souls (the Chinese theory is that the mortal body has two souls, the higher intellectual Hun and the animnalistic P'o). They drank blood, but only because it was the richest source of chi. Older ones could steal it from your breath, or even from the environment around them.
But the real kicker is that they are not a disease, nor are they 'cursed' in the traditionally vampire sense of the word. They were people to whom bad things were done, or who did bad things. Not everyday bad things but horrible, hell-worthy bad things. And that's what happened - their soul (the hun part) went to hell. And then fought it's way back out, and possessed its own body again. Then other kuei-jin would capture the animalistic vampiric monster that tore its way howling madness and insanity from the grave, and re-educate it. You screwed up, you went to hell, this is your chance to redeem yourself. You are a monster, be a proper monster in accordance with the rules made by Heaven itself or you will be destroyed.
So, it's not so much angsty, 'I never wanted to be like this', or 'oh woe is me, I must drink the blood', it was 'this is your own damn fault, bloody deal with it and accept the fact you're a monster and have to learn to be one properly or else!'
And interestingly enough, White wolf used Kindred of the East as the basis for all the new World of Darkness rules systems they are making now.