Predator x Human (marine/colonist/scientist)
Based on the Predator/AVP universe. I have two ideas for this one. These might be better for a group, but in my experience group games tend to be slow moving and wind up dieing way too soon.
1) Basically a dishonored Yautja(Predator) is abandoned alone on a planet. There is no worthy prey, no technology, and no way off of the planet. For many years he's left alone, that is, until the humans arrive to set up a science outpost. He jumps at the opportunity for a thrilling hunt, but it is not his blood lust he seeks to satiate.
2) A Yautja clan ship enters into orbit over its ceremonial blooding grounds. The planet is 'seeded' with xenomorph eggs in preparation for the youngbloods' first hunt. However, unbeknown to the Yautja, humans have recently colonized the planet and are quickly caught in the middle of the ceremony. The only survivor of the colony, a human female, earns acceptance into the clan.