So, as we draw closer to the time when I'll be able to kick start this thing I have come up with a few setting elements that I want to run by you guys.
First the cornerstone of a supers game, powers:
I envision a few basic categories of powers, those being:
Savant: Powers, which are really non powers. These are the mundane skills taken to superhuman levels (Batman, Hawkeye, the Punisher) type of abilities - they don't count as powers for purposes of mechanics (unless they are built as powers) and should generally bend but not break the limits of what a mere mortal can accomplish. Savants in the setting will be recognized as such once their talents become known, and certain parties will be aware that the reason they've suddenly begun appearing in huge numbers is because the awakening of the old gods has, as it always did in the past, fundamentally altered the boundaries of what is and isn't possible.
Descendant: A subcategory of humanity that is capable of directly wielding superhuman powers because it's in their blood. This comes from having an ancestor who was a god or one of their nonhuman creations. These are your mutants, your science accidents like Spiderman, and your outright aliens. A very small portion of the human population has the genetic potential for superpowers, but not all of that portion get exposed to the catalysts that activate their specific powers - and the conditions required are unique to each individual, though proximity to other descendants seems to somehow raise those odds.
Wielder: Powers derived from an external source, be it an ancient magical weapon, a suit of power armor, or a chemical concoction that grants powers when you ingest it. The universe goes out of its way to not part a wielder from their source of power permanently, though it can and has happened before. These Powers should obviously have the Device flaw.
It is possible and probable to have powers from more than one category. Peter Parker had spider-powers, but he was a genius who concocted his web fluid and invented his webshooters himself: a fine example of a Descendant/Savant.
These are categorizations that are widely known and accepted in the setting among those who are in the know about such matters.
I'm working on the gods now. I need to make them just right...cthuloid, but still comprehensible and compelling on a level that would make you go 'I can see why this eldritch horror has followers'.