Well, given the enthusiastic response, let's talk setting and power level. All interested parties give me an idea what kind of setting elements you want, and where we'd like to start power level wise.
My idea was to split it between roleplay/side story scenes and action/mission scenes. At the end of a given thread, power points would get awarded. I would want to give out pretty good amounts of Power Points so we don't have the usual problem of feeling like you're getting nowhere character-wise. We would keep the action in the mission scenes fast and furious and let side scenes go at their own pace. With a max of 5 players to start I could easily juggle some more personal plots.
My setting idea, which is open for suggestions to make it better/more fun:
-Rise of the Old Gods. In this one ancient and very large godlike beings start appearing and fucking shit up in a big way. These are the original rulers of the earth who have been dormant for longer than recorded history, and something - maybe lack of faith, maybe a crazy cult messing with powers man was not meant to mess with, or maybe just because their nap time is up - has awakened these massive inhuman entities of vast primal power.
Naturally, somebody needs to do something about these guys, and that's where you come in. One of the gods does not want the others ruling over the earth, so it summons the descendants of its former high priests and gives them powers and their marching orders: beat that godly ass and save the world, because these other gods are seriously harshing his mellow with their mass destruction.
Now most conflict would be with minions of the other gods - they had their own high priests too, and plenty of people willing to obey beings that are obviously hella powerful.
So, thoughts and suggestions?