Anyone familiar with RWBY? Okay, if not, shame on you! Check out Roosterteeth's site or their Youtube Channel and watch the two seasons they have out of it!
If so, the concept is based on this series of Future AU Images:
Ruby Rose: http://i.imgur.com/gDBz6d3.jpg
Weiss Schnee: http://i.imgur.com/WmOYtdH.jpg
Blake Belladonna: http://i.imgur.com/R0ZNdoA.jpg
Yang Xiao Long: http://i.imgur.com/Kh6bSLn.jpg
Setting: Shadowrun, Year 2070-2075, would take place in Australia which in my version has been free of most non-Aboriginal civilization for quite some time due to an abundance of magical Flora and Fauna (Awakened Dingos and Drop Bears, anyone?) that basically overran human civilization early into the Sixth Age. It's only been in the last couple of years that returning humans have managed to start making a foothold from the shores and moving in, which has resulted in a VAST number of job openings for Paracritter Hunters, which is where the team above would come in. Of course, with all of the megacorp city-states, a regrowing urban population of metahuman (or human and SURGE only, to be determined), the action would not necessarily be limited to Paracritter fights...
Design: The team above would be composed of 3 Adepts and either a Mystic Adept or Magician (For Weiss, of course), and character-gen would be easiest in 5th Edition because of the Priority system and the fact that it'd have to be fairly structured how the designing would go. I'd be looking at capturing the characters and the RWBY feel while using a system I know and love and can actually RUN with relative ease... and yes I would be looking into making custom weapons to emulate the weapons of the show...
So... any interest, by chance?