Well its one of the five great cities in the Valley of Siddim and vampires are in a rather tight spot someone is hunting them, and that never happened before. So the new vampires recently brought over are favoring concealing themselves among the mortals and being more discrete, while the elders and the old guard just walk around in the night and everyone knows they are vampires. Not that they care save the elders have been coming down hard on the more immoral practices (child brothels and certain excesses) and have the power and resources to do so, except in Sodom. So in some ways being a vampire is easy its a very promiscuous and hedonistic society and the Kiss is very pleasant and the vampires tend to be weall off if not very wealthy. Orgies are common at the temples and drugs common so feeding is a matter of either owning a slave or strolling down the street and hiring a whore, or just taking some mortal you like after asking. But the new ones are hiding and making hunting them harder but having to work more to secure food sources discretely.
Some themes will be elders verses the young, the hunters being hunted, dealing with your humanity when the society is immoral by modern standards and very much so in some areas and of course forging your own path and a clash of faiths the native ones verses the alien concepts of the Hebrews and their One God.
I would like at least two or three players, all must be Daeva or Mekhet, both would be regional enough. Other clans would have to be argued and a case made that makes sense. Gangrel and Nosferatu are European and the Ventrue appeared just around the time of Rome so they are out. Mekhet are from Egypt so they are not impossible although the main clan is the Daeva, Ur is closes to the area so they reached the cities first, but they are not Covenant based a vampire that behaves is welcomed.