I've personally been toying with the idea of running a Vampire game, since I have time, and a plot/setting in mind. But...
I don't think my games are for everyone. I try to capture the horror of a Vampire game, with a cup of political machinations, a healthy dose of thriller and a dash or two of action movie...if that makes any sense at all. Also, while I do like the setting and lore behind Masquerade, I despise the system...certain disciplines and skills are very unbalanced, and while I tend to trust players not to abuse them, it can lead to trouble. For this reason I like to use the NWOD system with Masquerade's clans, Camarilla, Sabbat, and setting in general. Theres a nice little translation guide available that makes this pretty simple.
With that said, I'd probably only update the game once, maybe twice a day if everyone's had a chance to respond. Slow and steady is my style with these things. Players would have to be patient and hopefully long-time members of the site.
Players would have to be pretty willing to deal with dark themes. Sexism, racism, and similar controversial topics may be present. I would list the game under 'extreme' not because I expect it to focus on such elements, but because if they come up, there would have to be a disclaimer saying 'you were warned.'
And, lastly, I really tend to push players on making realistic characters. I like a back story to justify certain skills (the ones above 3 dots, generally) and if I don't really see how it connects with your concept I reject it readily.
So, I guess if we somehow found a group of players willing to submit to that stringent dogma, I would love to run a V:TM game set in Washington, D.C., 1963. But if anyone is a less demanding storyteller you may wish to look at them first. ^_^;