I don't know if rules would work the best, here. I, for one, am unfamiliar with many rule-based roleplaying games, other than D&D. I think free-form would be better anyway since combat can be a bit more frenetic in Resident Evil than a rule system would allow.
And, what "universe" do we want? Do we want to have it take place post-R.E.4, what characters will be involved, et cetera.