I've decided to host it in the city of Kibou, basically much like Lyran but in a far more advance state of decay. It is also owned by Rokujou Inc. and is located somewhere near where Kyoto Japan would be. It is far more a dystopia city then Lyran is, so punishment and authority is even more harsh. There are also far more crime and is home of multiple criminal organizations merged together to form one authority about, often paying off Rokujou Inc.' military business and even buying some of their aid to hold their grounds. The south-east quadrant was completely sealed off from the rest of the city due to a dangerous viral outbreak from the harsh realities of the outside world through an "accidental" leakage. The part of the city still has life, but it is usually made as a means of a prison for criminals and a fertile crescent of other dastardly deeds that would make the staunch citizens flinch in disgust.
The city is based more in an compass shape [eight points] over the cross design of Lyran. It isn't as large as Lyran is in width based on points, but it makes up with the multi-layers going to a surprising eight layers. Four above level, four underneath. The four underground are used primarily as industrial means and low rent, low priority homes for those who are poor.
Being another city owned by Rokujou Inc., it as well has introduced Nephilims within the system to go around with Byts. Only the military, private business above ground, wealthy and a few lucky individuals who came across one, actually owns a Nephilim.
Although the city is owned by the corporation, it still allows it to police itself with independent detective agencies and police forces as a part of a social experiment as well, is a bit more lenient of having children then Lyran [Lyran is primarily based on gene augmentation from two parents and born in a Symbiosis Womb Machina instead of actual conception between two adults.] given they have the proper authorization for child birth and ability to keep the child up. Accidents do happen although as they forgo the "serum" to keep them from being able to copulate and usually ends up with a heavy fine and the child is taken away and sent to a foster parent [although a few turn up missing within the seams and never heard from again].
Kibou as well has an active resistance as it seems the resistance against the corporation is multi-city based and have not been exterminated. Although the resistance have been nearly destroyed multiple times, it seems to come back just as strong as it was before.
Kibou is also a multi-ethnic based city, keeping to not just the Japanese, but immigrants from various other nations live there, boosting the languages required to two primaries. Japanese and English and thousands of other dialects and tongues from various other ethnicities.
As well, the Awakening although having started in Lyran has also happened here in Kibou. The "self aware" business between the Byt and Nephilim beings are kept more hushed and dealt with quickly with the detective force owned by the Rokujou Inc. to keep it on the down-low to keep from wide-spread panic that masses "play things and basically slaves" now have a free will of their own and often react violently to a harsh owner who used them merely as tools. A small portion of Nephilims and Byts work actively with the resistance against the city, often posing as mindless automotrons before going about their rounds and causing mayhem.
These various plot-hooks and other tidbits offers a lot for players to go with. I hope this helps with various other questions as to where the story and such takes place. It may not be in Lyran and does not possess SPE#3318, but it does give enough significance as the city finds life of it's own.