Those ladies from the Hack/Slash comic look absolutely amazing. I can imagine them going through a creepy mansion, running into all sorts of 'unpleasant' creatures. Ghosts, monsters under the beds, and hiding in the closets... And even more.
Going above that, the lovely Miss Jessica could really use some more attention, as you said, and deserves her own game. And your idea, of her being chased and trying to avoid the attentions of certain individuals sounds fantastic. Something tells me some men might be particularly difficult to shake off.
And then, below that, the 'typical' final girl heroine looks quite pretty. I wonder what she'd be willing to do and go through to remain the last girl and possibly escape from whatever the villains are. Or even, perhaps eventually, if she'd want to.