I've been re-watching Naurto Shippuuden and a rather off the wall idea came to me. Anyways, here it is.
The Sixth Hokage (Naruto Uzumaki) and The Leader of the Hyuga Clan (Hinata Hyuga) had twins. While the twins were not identical, they were close nonetheless. As the twins grew, the boy would take after his mother and the girl after her father. As they grew and trained, they became a formidable pair, a match and more for any challenge thrown at them.
When they completed their training as Shinobi, through fate or destiny would end up on the same squad. They ended up paired with a third, a medical ninja with exceptional abilities in his/her own right. As so the squad members become known as the Terrible Trio.
I'd be looking to play the brother. For this idea, there would need to be someone to actually run the game as well as the other squad mates.