Well, I'm very familiar with Kuno's Ghoul Street Sam (we've known each other a while), and I know she's been dying to play her, but all the GMs have been "Ghoul! Yeep!" and such.
I currently have a triad of character concepts that I've been wanting to play.
1 - An Adept Weapons Specialist, street name Ghost. I've had chances to test him in an RP situation, and he's kick-ass. Can pull quadruple duty: combat heavy, combat medic, group weapons monkey (he has an Armorer shop, and a Firearms specialty, plus an Arms Dealer contact), and part-time wheelman.
2 - A Changeling Street Doc, street name 'Doc.' Also an Adept, but his powers focus more on boosting his non-combat capabilities (he took the Analytics power, for example), but he's capable in a stand-up fight.
3 - Human Technomancer. Only real problem I find with Technos is that, without the advanced ruleset for them, it's much easier to play a mundane Hacker, since you can just buy most of what you need from the get go, and then do so more later.