Well I don't get the opportunity to get wasted enough to have a problem...something like once every two years. It's just fun to do once in awhile for me at least. And I can drink way more than the average person can and not get sick at all, still walk a straight line, say my alphabet backwards--fast, and spin in circles and still not get sick or be dizzy. I don't know why, and I actually have a very low immune system, so is that what you meant or the other way around. When I was still young and stupid (18) I actually drank 68-oz. of straight Everclear in less than two hours and showed really no effects from it. No hangover, nothing. All that said, I never drink around the kids, and I never drive if I've had even one drink because that's just stupid.