Alright, I'm running a few things right now and am only playing in one. But, there are a few things I've had a major hankering for. I can't run any of them (currently running one group, starting a second, and possibly starting a third), so I'll put a call out for GMs/Mods who might be interested (in each case, I'd prefer to avoid "fandom" and would prefer a Group, if at all possible):
1) Urban Fantasy - I don't much care what, but urban fantasy either modern or near future, Earth or original world. You know the thing - vamps, weres, magi, and such, either in hiding or not. The one thing I can't abide in this sort of group is "Charmed"-style witches or such. I'm cool with anthros in such a setting too.
2) Vegas with a Twist - Some sort of "sin city" (gambling, etc.) with an F/SF twist; could be medieval fantasy, space opera-style, whatever.
3) More recently, and more nebulous, I've had a bit of a hankering for a secret society/agency type thing. Like monster hunting, alien control/hunting, something along those lines. Maybe government agency, ancient secret organization, whatever. I suppose something along the lines of a MiB, Torchwood, Special Unit 2, or something, but not exactly those.