I like the idea, however, of creating our own Universe. I do enjoy the idea of playing in the Ultimate Universe simply because it's possibly the less contrived universe out of all the Marvel Universes, with the sole exception being the Mutant X Universe, which I enjoyed (I have a predisposition to like Havok, sue me).
However, I thought that maybe we should craft our own alternate Universe. Something crazy like, Dr. Doom captured the Scarlet Witch and eliminated the mutant genome in human beings utilizing Hex Magic, which attracted the attention of Celestials because the mutant genome was a part of their cosmic experiment. The Celestials then began the systematic destruction of the planet, until a band of heroes united to fight these living Gods. In defeating the Celestials, many of these heroes perished-- giving way to a new breed of heroes, inspired to greatness by the sacrifices of those that came before them.
Where does the timeline differ, exactly?
Dr. Doom and Reed Richards never attended the same university, so in this society, the Fantastic Four do not exist. However, Reed Richards is in possession of the Ultimate Nullifier, which was necessary to defeat the Celestial threat. Back to Dr. Doom, he instead went to school with Charles Xavier and Eric Lesshner, who became Magneto. The three were great friends until something catastrophic happened: Magneto accidentally killed Dr. Doom's mother. This led Dr. Doom to wage war against mutantkind, and set off a war between the three.
The reason why Dr. Doom never went to Columbia (or Empire, or wherever he went to school) was because of his own doing. Dr. Doom, in the 616 Universe, went back in time to fix Latveria's standing with the world, but set in motion this universe.
OR SOMETHING LIKE THIS.