Cthulhutech is a near-future setting where we discover magic, real magic (of the lovecrtaftian bent), and proceed to science the shit out of it. Magic, and the Arcanotechnology born of it, gives rise to a whole new era of progress, advancement and medicine. Society advances at a rapid pace, and for a while, it pretty much looks like we are on the cusp of utopia, with only the tiny little downside that our tech will actually drive you nuts if you understand it too well, but dont worry! We have therapists!
But you know, the universe runs of murphyonics.
Turns out theres a alien colony on Pluto. The aliens are called the Migou, and consider us humans to be extreme aberrations because our sapience comes from a purely biological source, our brain. Every other species apparently uses its Soul to make up what biology lacks, but not us! This makes us non-people as far as they are concerned. Nazi level racism). Now, we were quite happily beneath their notice, until we began our gleeful embrace of magic. The threat we could one day pose, coupled with the fact that there are things sleeping on Earth that they would rather we didnt wake up, lead them to decide to kill us all.
But you know, smug superior aliens, didnt bother to do it themselves. They whipped up a whole new race based on us humans called the Nazzadi (jet black skin red eyes, night vision sharp teeth) and invented a history and culture for them. The Nazzadi happily went to war with us, but eventually the ones In The Know got sick of it and revealed the truth to everyone else. Peace was had, we gave them Cuba to make a homeland for themselves, and we all prepared for the coming of the Migou.
Who turned up right on schedule and began fucking our shit up, starting at the poles where its too fucking cold for us, and invading south and north there.
Meanwhile all this was happening, shadowy conspiracies dedicated to lovecraftian horrors had made a comeback with the rediscovery of magic and were setting about their own schemes.
One group that managed to take over a HUGE coporation dreams of turning humanity into a monstrous mythos race (subservient to them, naturally), these Dhoanoids can appear human at will and are only really detectable by genetic testing. Luckily they lost the real mojo before they could really get a firm grip on it, said mojo ended up in the hands of rebels who dedicated themselves to stopping said evil conspiracy by using the lore they stole to achieve symbiosis with extradimensional horrors and becoming a alltogether superior form of mythos being that is both more powerful and completely undetectable. Meanwhile, a entirely separate group lead by our favourite Order of Dagon have basically taken over the oceans and are looking very very hard for Ry'leh. They have basically become a threat to the entire planet's coastline and love to kidnap people for their unprotected sex rape parties. Its~Starting~Look~Alot~Like~Fishmen! And if that wasnt enough another evil cult managed to actually pull of a summon-the-eldrich-god ritual and they have kinda eaten most of asia. Leng is a bitch.
Of course, we are making our own strides, some humans are developing psychic powers entirely separate from magic (called Parapsychics) and those guys have all sorts of interesting abilities, provided we can get them pointed at the badguys instead of going on murdersprees. We also figured out how to make something distressingly like a Evangelion-by-way-of-lovecraft called a Engel that are a match for the Migou's technorganic mechas (as long as they dont go apeshit and start eating people Attack On Titan style). And so on.
Currently, most people live in massive enclosed fortress-cities called Archologies, and your average person lives a life of material plenty, ample entertainment, and extremely casual attitutes towards sex, drugs and rock n' roll. On the streets there is a neverending battle between militarized polices forces and criminal activities, special investigators who might as well be Inquisitors and the cults they hunt. In the shadows, Tagers weild monstrous power to fight a conspiracy intent on corrupting every level of human society. While on the battlefronts, we are kinda losing to the north and south, where our Mecha-based fighting forces are outmatched by the Migou's superior tech, and there are too few Engels yet to swing things in our favour. We are also losing to the East, where a elder god is kinda eating everything (including physics) and his Reaver(sec: firefly)-like minions push to widen their new land even further, overrunning us with sheer numbers. Also every beach and coastline except for a few heavily defended exceptions are basically open-game for the Dagonites.
But dont worry! We got this!
In terms of playing a muggle, your basic options are the FSB (Federal Security Bureau, think FBI) who are basically suped up mundane cops who go after criminals and the like, and the OIS (Office Of Internal Security, think CIA with no restrictions what so ever), who are basically Inquisitors/Spectres/insert-preferred-fictional-superlegal-investigators, who are charged with protecting humanity from 'monsters', and you basically have no rights unless they decide you do.