Cleopatra, The Queen of The Nile probably set the standard for males and their modern female harems. Perhaps she also had a weakness for female slaves? She however had male and female harems if she desired them. And of course there was Marc Antony. This rp would revolve around the fall of Cleopatra. Perhaps a member of her harem saw an opportunity for power if he controlled Cleopatra. Maybe he gave her a drug that a female slave devised and would kill her if she were not given an antidote on a daily basis and the slave would only give it to her if she did as told. Perhaps a male a and female slave worked together? Perhaps this way he/she not only controlled her for his sexual pleasures but also as a way to manipulate her into giving him/her power slowly.
All up for discussion. Just always wanted to do a rp based on her last days.