I wish they'd made the ones they did more faithful to the original H.P. Lovecraft works, "Herbert West: Reanimator". While I appreciate the more modern touches, I think it's somewhat more macabre (and less Peter Jackson-esque in terms of similarity to Brain Dead) to watch West's slow descent to the point where he'll murder victims to obtain fresh specimens. But I don't think Adrien Brody would be a good choice. Jeffrey Combs was always so perfect, I can't think of anyone today who really resembles him well enough (maybe Stephen Colbert if he could get serious, but aside from him, I'm coming up blank).
Stuart Gordon directed quite a few films based around Lovecraft stories, some are fairly decent despite deviating from the originals. What I'd really like to see is a big-budget, modern production of At the Mountains of Madness. Now, THAT would be a great use of Lovecraft storytelling. Surprised we haven't seen much of that lately, actually.