I used to be scared of spiders, once a Wolf Spider the size of my thumbnail crawled up on my chest and I jumped and freaked, he took off and I never saw him again. He was as scared of me as I was of him.
I'm a lot more comfortable with spiders now, this past summer I found a spider at work, I don't remember which it was (though I looked it up at the time) He was some kind of jumping spider, a hunter not a webbuilder. I picked him up and took him outside so he wouldn't get killed by the chemicals we use to clean the tables, I can't imagine those aren't toxic to spiders. He didn't like being picked up very much, he was probably unhappy my hand was too warm or something. He kept trying to get down since I'm too tall, I was able to put him outside where it was safe and more likely to find food.
I've seen other spiders I tried to help play dead though and I left it thinking I had drowned it accidentally trying to help it out of the water. I came back later and it looked fine, maybe it wanted to be in the water?
Anyway, most spiders in Indiana are pretty harmless, supposed to be on the edge of brown recluse territory, but I don't think I've ever seen one.
Well, striped spiders look a little more ominous to me.