I think so?
The setting itself could be forgotten realms/eberron/etc....i am rather open on that still, but basically this is just an interest check. I will accept most standard/homebrew/monster races with a standard character level around 12-16, I won't be demanding rolls for everything the characters do, i figure you can climb a rope or knock down a door without having to prove it for example.
Combat will basically be decided by a d20 roll, in that each character would need to roll 20 (either at once or cumulatively) in order to beat the more basic monsters, higher level monsters will be set at 100 points with the group having to earn that much through d20 rolls to be victorious in combat.
All races/classes/paragon paths are acceptable, but initially we would need to decide on a Campaign Setting.
If you have a preference, let me know.