I propose a game if we can find a GM using the VtR rules in a smaller city maybe no larger than 250,000 (50,000 plus 50,000 people per vampire PC would be decent) here due to circumstances players would be the only Kindred maybe supported by an Elder who is there due to it being available now. Perhaps the old leader went Revenant and killed his peers leaving an empty city or something else happened far enough to make it inviting to go in. As I see it if players have to deal with each other it will keep the game more active role-playing between players driven by with few others to have to deal with save an NPC elder. It would be far more intimate and easier to run I would think for the ST.
Alternatively a game within one Covenant or Clan something more intimate and where the characters are together for a reason with some glue to get them to work together, at least interact, to some degree in an understandable way.