I'm up for this.
There could be rival dragon clans, with the characters that we play belonging to these clans, which would be an explanation for the rivalry between them, being bitter enemies and fighting one another if they happen to cross paths.
I've been researching Dragons and Dragon folk for a while now and maybe an interesting twist could be that the characters are dragons, but they have the ability to change into humans. There are several places where information about this kind of thing can be found, one of which is actually a book about drawing and painting dragons, several of the pages show human to dragon transformations.
The setting could either be in a modern world, such as todays world, which would lend more credence to the transformation ability because of the need to disguise our characters when in the human populace but with the dragonic overtones to add a fantasy setting to the story, or it could be set in a totally fantastical world, where there are all the usual races such as elves, dwarves, trolls and the like for us to interact with.
Of course being dragon characters there would be others that are after us because the characters are of course beings of legend, to slay a dragon is the highest achievement a Knight or hunter could hope to gain, because of the rewards and fame that usually follow it. Now with this in mind, would the characters be aware that they are being hunted, or would it be something that could be worked towards, so there could be the characters in the world, interacting, unaware that somewhere in the land there are still dragon hunters and Knights that are seeking to make a name for themselves, or do we have them aware, being cautious, keeping a low profile and avoiding their dragon form as much as possible.
These are just some ideas I have, I dunno if they help you out at all, but yeah......