The Standard Western Grimoire of Horror Monsters is getting pretty played-out. I like vampires on the classic Bela Lugosi / Count Dracula model, but that can really only be done so many times before it deteriorates into campy schlock (as in fact happened to Dracula for most of the 20th century, except his brief revival / reinvention in Coppola's hands). I didn't mind the Anne Rice / Vampire Lestat approach to vampires for a while, but Rice has a lot to answer for in that she really started vampires on the road to sentimental, pretentious pseudo-eroticism that gave us World of Darkness, Blade and Underworld along the way before arriving at the awful nadir that is Twilight. 30 Days of Night is a game attempt at resurrecting the vampire as a primal threat, but its feral approach would make just as much sense (perhaps more) for werewolves. I think the next reinvention of the vampire will need to be something completely different from the Eastern European legends (there are plenty of candidates in other parts of the world).
(For that matter, zombies have pretty much jumped the shark, too. Too much of Standard-Issue Zombie Mythology makes no sense, and you know a Horror Monster is descending into the hell-realms of CampSchlock when it starts turning up in rom-coms.)