I would agree. A Rogue Trader or Inquisitor style (Visions of a group game ala Eisenhorn comes to mind) seems to have potential. The downside that I've run into before here on E is when the game tends to be a bit more wide open, even Rogue Trader style. So you've got someone who's basically an enhanced human perhaps with a large fortune, then you've got someone playing who's an exiled Eldar, former Sisters of Battle, etc, etc, etc.. It's just too wide of a gap to even be realistic, no matter how cool it may seem.