Well there are organisations known.
The Shi of Spire for example keep mostly to themselves, and nobody really knows what goes on in their yellow skinned, tilted eyed, black-haired heads.
In the nearby city Cover, just across the bay, they still have electrical lights up and running, and some big machine running to travel about the city. But they are a bunch of assholes, not wanting the Spire people to go into their city, keeping them several miles out of the city actually. (There's no real secret though, it's just a city founded by more recent emergents from a Vault)
Five years ago, a dragonfly machine was spotted, ancient texts calling it a helicopter, but it disappeared furter west and expeditions that tried to find it never returned.
Ordinary human makes you human, your ancestors aren't of much import, unless they are to your character. No ghoul, no mutant, just human.
That's about it.