Some of it is a matter of power level all the same. I mean.. even in Annihilation. Firelord fights his way through an entire alien spacefleet on his last defiant strength, only dropping after he brings down their leader. The Kree turn their entire capital city into a weapon against the forces from the Negative Zone. The Silver Surfer in rage and sorrow tears open space to create a singularity to prevent the body of his friend from being defiled.
Or there's the JLA, with Superman grappling with the angels of God, the JLA forcing back the moon, the.. entire start to finish arc with Mageddon, the centuries spanning clashes and strategies of JLA one million in moves and countermoves of Galactic conquest across time and space.
Or Thor and Asgard in a futile glorious stand against the Celestials themselves that though completely and sort of obviously doomed from the very beginning is awesome to behold right down to Thor being the only one left, hurling his father's twenty foot tall, empowered by all the pantheons of man, sword through the body of a Celestial as he shouts one last curse.
Or.. I mean I thought the ending of War of Kings was rather lame, but until then it gave the feel of pan galactic war between massive empires and their superbeing champions.
It's the scale of mythmaking that underscores those sorts of stories, and to see a sort of dismissive "it's just masturbatory wish fulfillment" well.. eh. All rp is a measure of wish fulfillment, at that. I personally never fathom the attitude towards wanting to use a comic book supers rpg, to emulate particular comics though, being bad or wrong or "something everyone should admit what it is". Is not being able to game like unto the comics part of why a supers rpg would exist?
That all said, honestly, to the fellow that started the thread, if you don't really have an interest in running that sort of thing, there's really nothing wrong with that, it was just an answer to the question "what would you like to see/are interested in?" Running anything you don't have much regard or enthusiasm for would just end badly and be unfair to you.
As far as opposition though? I mean, just look to the comics themselves for examples. And builds, well, it is just a matter of saying no straight up to anything insane.