The farm was an experimental research lab specializing in genetic hybridization. For years, the scientists had been elevating animals to almost human levels. They succeed in created anthromorphic creatures that were a mix of the human and animal forms. Despite their advancements, the animals were treated like... well... animals.
Then came the day of revolt. The animals escaped their prison and caged the scientists. Now it is the scientists turn to be experimented on and treated as pets.
We will need hybrids (both dominant and submissive) as well as the captured scientists.