Just got a rough idea, that I will refine over time, with the help of some thoughts from others. The basic gist of my idea is either high school or college based; it would be modern day, but with a twist of fantasy. Obviously, if we go the high school route, the characters we play will have to be in accordance with Elliquiy's policy on age (which, if i remember correctly, means 16+; on the safe side, I'd just assume make everyone an 18 year old senior, hence the topic title).
After play has been going on for a little bit (probably two weeks irl, enough time to give players to socialize and interact), something big would happen. The 'big' thing that happens is inspired by the Shadowrun tabletop game; HOWEVER, this is going to be a SYSTEMLESS game.
Basically, people will just start changing. The change will be fast and brutal (lasting minutes, and striking at any time), and will be pretty "wtf!"-ish. For those who have played Shadowrun, this was called Goblinization. For our purposes, I'd probably pick a different term, but the core idea is similar to the Shadowrun one. People change all over the world, and nobody really knows why.
I'm sorry if this was a bit of a jumbled mess; my thoughts are pretty rambling at this point. So, anyways...anybody interested? Got some ideas or questions? Feel free to post away.