It's hard to say how many would be too many if we don't have a DM. I'd think 5 players, max, but that's just me. I may have started this thread, but I don't really 'claim' it. I would also hesitate to make it 'first come/first served' or just open it up to anyone who shows interest. If we DO have a GM, we'll need to filter the group. For instance... if the GM feels like running a tactical-heavy game, I'd think that us angst-lusting types might be less inclined to enjoy it.
I really mean that I hate playing with people who insist on playing some abusable, obscure fucking class that nobody knows anything about. There will always be min/maxing or powergaming or munchkining-- whatever you call it or however you feel about it. But I prefer the rules to be minimal to support the story rather than dictate it.
As for setting, Muse? I kind of like the suggestion of a minimally-developed world. We could do a Twilight-Zone-ish setting, or we could do a single setting like Greyhawk, Eberron, FR, Dragon Age, er, what's the Steampunkish 3rd party game, Iron Kingdom? Can't remember.
Anyway... I'd be up for it, for the most part, if we can find an interested GM.